| Hamilton Watch Company | Bienna, Lancaster | 1892 |
| Hanesbrands | Winston-Salem | 1 de janeiro de 2000 |
| Hasbro | Pawtucket | 1923 |
| HCA Healthcare | Nashville | 1968 |
| Head | Kennelbach | 1950 |
| Helicópteros Hughes | Mesa, Culver City | 1947 |
| Henry Ford Company | Detroit | 1901 |
| Hershey's | Hershey | 1894 |
| Hewlett Packard Enterprise | Spring | 1 de novembro de 2015 |
| Hewlett-Packard | Palo Alto | 2 de julho de 1939 |
| HGST | São José | 2003 |
| Hiller Aircraft Company | Firebaugh | 1942 |
| Holiday Inn Express | — | 1991 |
| Holland America Line | Seattle | 1873 |
| Hormel | Austin | 1891 |
| Hornady | Grand Island | 1949 |
| HowStuffWorks | Atlanta | 11 de julho de 1998 |
| Humana | Louisville | 1961 |
| Hupmobile | Detroit | 1909 |
| Hyperion Solutions | Santa Clara | 1981 |
| IBM Research | — | 1945 |
| Id Software | Richardson | 1 de fevereiro de 1991 |
| Illumina | San Diego | 1998 |
| ImageShack | Los Gatos | novembro 2003 |
| Imation | Oakdale | 1996 |
| IMG | Nova Iorque | 1960 |
| In-Q-Tel | condado de Arlington | 1999 |
| Indeed.com | Austin | novembro 2004 |
| IndyMac | Pasadena | 16 de julho de 1985 |
| InFocus | Tigard | 1986 |
| Infor | Nova Iorque | 2002 |
| Informática | Redwood City | fevereiro 1993 |
| Instacart | São Francisco | 2012 |
| Instituto de Engenheiros de Rádio | — | 1912 |
| International Flavors & Fragrances | Nova Iorque | 1958 |
| International Swaps and Derivatives Association | Nova Iorque | — |
| Interpublic Group of Companies | Nova Iorque | 1961 |
| Invicta Fighting Championships | Enka | 2012 |
| Invicta Watch Group | Hollywood | 1837 |
| Invitrogen | Carlsbad | 1987 |
| Iomega | San Diego | 1980 |
| Iridium | McLean | 2001 |
| IRobot | Bedford | 1990 |
| Iron Crown Enterprises | Virgínia | 1980 |
| Iver Johnson | Jacksonville | 1871 |
| J. B. Hunt | Lowell | 1961 |
| J. C. Penney | Plano | 1902 |
| Jack Daniel's | Jack Daniel's Distillery | 1866 |