| RCA Corporation | Rockefeller Center, Nova Iorque | 1919 |
| RE/MAX | Denver | 1973 |
| Red Hat | Raleigh | 27 de março de 1993 |
| Redback Networks | São José | 1996 |
| Remington Rand | Buffalo, Nova Iorque | 1927 |
| Remote Control Productions | Santa Mônica | 1989 |
| Republic Airways Holdings | Indianápolis | 1973 |
| Revell | Elk Grove Village | 1943 |
| ReverbNation | Durham | 31 de outubro de 2006 |
| Revolution Studios | Los Angeles | 2000 |
| RhythmOne | São Francisco | 2004 |
| Rite Aid | Filadélfia, East Pennsboro Township | 1962 |
| RJR Nabisco | Condado de Cobb, Winston-Salem, Nova Iorque | 25 de abril de 1986 |
| Robinson Helicopter | Zamperini Field | 1973 |
| Rocketdyne | Los Angeles | 1955 |
| Rockwell Collins | Cedar Rapids | 1933 |
| Room to Read | São Francisco | 2000 |
| Rough Draft Studios | Glendale | 1990 |
| Roxio | Santa Clara | 2001 |
| Royal Caribbean Group | Miami | 1997 |
| RR Donnelley | Chicago | 1864 |
| RSA Data Security | Bedford | 1986 |
| Ruger | Southport | 1949 |
| Ryan Aeronautical Company | San Diego | 1934 |
| Ryder | Coral Gables | 1933 |
| S&P Global | Rockefeller Center, Nova Iorque | — |
| S. C. Johnson & Son | Racine | 1886 |
| SAE International | Warrendale | 1905 |
| San Diego Football Club | San Diego | 18 de maio de 2023 |
| San Diego Studios | San Diego | 2001 |
| Sanmina-SCI | São José | 1980 |
| Sara Lee Corporation | Downers Grove | 1939 |
| Schlumberger | Houston | 1926 |
| Scholastic Corporation | Nova Iorque, Scholastic Building | 1920 |
| Scripps-Booth | Detroit | 1913 |
| SDI Media Group | Culver City | 1965 |
| Seattle Computer Products | Seattle | 1979 |
| Sekai Project | Norwalk, Los Angeles | 2007 |
| Semrush | Boston | 3 de agosto de 2008 |
| Sharpie | Oak Brook | 1964 |
| Shelby SuperCars | West Richland | 1999 |
| Shen Yun | Deerpark | 2006 |
| Sherwin-Williams | Cleveland | 1866 |
| Shield AI | San Diego | 28 de maio de 2015 |
| Shiny Entertainment | Laguna Beach, Newport Beach | 1993 |
| Showtime | Nova Iorque | 1983 |
| Shure | Niles | 1925 |
| Sigma-Aldrich | St. Louis | 1976 |